Fine-Tuning Pharmacogenetics: Paradigm for Linking Laboratory Results to Clinical Action

Fine-tuning pharmacogenetics: paradigm for linking laboratory results to clinical action.

Pharmacogenetics (PGx) is the study of the relationship between gene-based markers and pharmacology as it relates to the processing and/or function of drugs. The clinical utility of PGx is embodied principally in the ability to predict either the most appropriate dosing of a medicine or the selection of a particular medicine for a given individual. This expectation has led to the concept of “pe...

Praxis: a Paradigm for Action Research

Action research is a research methodology with a dual purpose (action and research). Action research as other research approach is led through a paradigm or a philosophical perspective. This article briefly describes paradigm, research paradigm and discuss about “which paradigm (positivism, interpretive, or praxis) does cover action research?”.

Adding pharmacogenetics to the clinical laboratory: narrow therapeutic index medications as a place to start.

A pharmacogenetics is a new discipline, it is anticipated to have applications in many fields, including drug development, therapeutic dosing guidance, and disease risk stratification. Rai1 has suggested that pharmacogenetic testing during drug development trials could create a large number of drug compounds targeted to particular pharmacogenetic phenotypes. This approach in turn would necessit...

Clinical and Laboratory Approaches to Hemophilia A

Hemophilia A is a worldwide disorder of coagulation system. It is a male disorder, yet females with hemophilia are rarely seen in communities with high rate of consanguineous marriages. The abnormalities in factor VIII gene transfer as an X-linked pattern in the family, affects as many as one-third of patients who had no family history of abnormality and thus the occurrence of a sporadic mutati...

The Fine-Tuning for Discoverability